We target over 300+ biomarkers for skin-gut-brain health

Clarify Within™ and Calm Within™ are designed to influence over 300 interconnected biomarkers tied to gut microbiota, nervous system balance, and skin health. While the full scope is extensive, we’ve highlighted a few of the most meaningful markers—those that reflect measurable, lasting change across mood, inflammation, gut barrier integrity, and overall skin function.

Why biomarkers matter

Most supplements claim to support stress, focus, or skin, but Clarify Within™ and Calm Within™ are built around what your digestive system, brain, and skin actually track: biomarkers. These measurable, clinically validated indicators reflect changes in your gut microbiota, nervous system, immune function, and more.

These biomarkers include:

• Neurotransmitters like serotonin, dopamine, and GABA, which affect mental health, mood, focus, and stress levels

• Cortisol and CRP, which are key markers of chronic stress and systemic inflammation

• Zonulin and tight junction proteins (Occludin, ZO-1, Claudin-1) that reflect gut barrier integrity

• Matrix Metalloproteinases (MMPs) and Collagen I, central to skin aging, elasticity, and skin barrier function

• Short-chain fatty acids (SCFAs) like butyrate and acetate, which regulate gut motility, barrier strength, and skin condition

• BDNF and alpha brain waves, crucial for cognitive resilience and central nervous system support

• Markers of oxidative stress (MDA, ROS), which influence everything from cellular aging to inflammatory diseases
  
  

By targeting these validated prognostic biomarkers across the gut-skin-brain axis, our formulations offer precision-based wellness support, backed by data from clinical trials and emerging science in human health.

Calm Within™: The biomarker-based brain supplement that works from within

In the world of wellness, true transformation starts at the cellular level. Calm Within™, our advanced brain supplement, is meticulously formulated to target key biomarkers that influence not just mental clarity and mood but also gut integrity, skin resilience, and inflammation regulation. This isn’t just another calming supplement—it’s a scientifically grounded formula that works through the skin-gut-brain axis.

Here’s how Calm Within™ supports your body, biomarker by biomarker:

Neurotransmitter support & brain biomarkers

Biomarkers supported:

• GABA, Glutamate: Balance excitability and promote calm

• Serotonin, Dopamine, Norepinephrine: Stabilize mood and enhance focus

• Alpha Brain Waves: Increased for calm alertness

• NMDA Receptors & BDNF: Support cognitive flexibility and memory

• Acetylcholine: Boosted for learning

• Tau Protein & Amyloid Beta: Modulated to protect neurons

• Doublecortin (DCX): Indicator of neuronal regeneration 

• ROS, MDA: Reduced oxidative stress and inflammation 

Stress, inflammation & cortisol regulation

Biomarkers supported:

• Cortisol: Lowered to benefit mood, intestinal microbiota, and skin inflammation

• Inflammatory Cytokines (TNF-α, IL-6, IL-1β): Reduced

• NF-κB, TLR-4: Inflammatory pathways downregulated

• PECAM-1: Reduced to support skin inflammation control

• HSPs, NLRP3: Cellular resilience and reduced neuroinflammation

Skin biomarkers for radiance & barrier function

Biomarkers supported:

• MMPs & Collagen I: Protected and stimulated to maintain elasticity

• AQP3: Improved skin hydration

• Sebum & Keratinocyte Proliferation: Balanced

• Wound Healing & ROS: Accelerated and defended

Gut health & microbiome integrity

Biomarkers supported:

• Zonulin, ZO-1, Claudin-1, Occludin: Strengthen the intestinal barrier

• LPS: Blocked to reduce systemic inflammation

• SCFAs (e.g., Butyrate): Production increased

• Faecalibacterium prausnitzii: Growth supported

• Gut Cytokines: Inflammatory markers reduced

Mitochondrial & antioxidant biomarkers

Biomarkers supported:

• ATP Production: Increased for cellular energy

• Antioxidant Enzymes (SOD, GPx, Glutathione): Activated

• MDA, Uracil Incorporation: Reduced DNA and lipid damage

Calm Within™ is your daily foundation for calm focus, clearer skin, and a strong gut-brain connection.

The synergy between probiotics, prebiotics, and postbiotics is essential to restoring gut microbiota balance and promoting both immune function and skin health, especially when targeted together through our Triple Biotic™ approach.

Clarify Within™: Biomarker-driven gut support for skin clarity, brain health & immune balance

True wellness begins in the gut—but it doesn’t end there. Clarify Within™ is a clinically informed gut supplement targeting dozens of scientifically validated biomarkers across the gut, skin, and brain. This isn’t just gut support—it’s microbiome-powered transformation that impacts your mood, skin barrier, inflammation, immune signaling, and neuroprotection.

Let’s break down the biological systems and key biomarkers Clarify Within™ is designed to support

Gut barrier integrity & microbiome balance

Biomarkers supported:

• Tight Junction Proteins (ZO-1, Occludin, Claudin-1): Strengthened

• Zonulin: Downregulated to combat intestinal inflammation

• LPS & Calprotectin: Reduced

• SCFAs: Butyrate, Propionate, Acetate levels increased

• Microbial Diversity: Enhanced

• IgA: Elevated for mucosal defense

• Autophagy & Bile Acid Metabolism: Supported

Skin health & barrier function

Biomarkers supported:

• MMPs & Col1A1: Inhibited and stimulated for firmness

• TEWL: Decreased to improve hydration

• Keratinocytes, Profilaggrin, Tyrosinase: Balanced

• IL-6, IL-22, S100A7: Inflammation markers reduced

Brain function, mood & cognitive support

Biomarkers supported:

• Neurotransmitters (Serotonin, Dopamine, GABA): Modulated via gut-brain axis 

• Alpha Waves, BDNF, Tau, Beta-Amyloid: Enhanced neuroprotection

• MAO & AChE Activity: Balanced

• HPA Axis (Cortisol, CRH): Regulated

• Glymphatic Function & Lipofuscin: Supported

Inflammation, antioxidant defense & mitochondrial health

Biomarkers supported:

• TNF-α, IL-6, IL-1β: Lowered

• NF-κB, TLR2/4: Downregulated

• CRP: Reduced

• ROS, MDA: Controlled

• Glutathione, Catalase, GPx: Antioxidants elevated

• ATP, mtDNA, MMI: Improved across the gastrointestinal tract and skin

Final thoughts:

In a world where wellness claims often outpace evidence, Clarify Within™ and Calm Within™ stand apart by targeting what truly matters: biomarkers. 

These scientifically validated indicators bridge the gap between your gut microbiota, skin health, and cognitive function, offering a tangible path toward long-term vitality. From strengthening the intestinal barrier and calming the nervous system to enhancing skin microbiome balance and reducing inflammatory mediators, every ingredient is carefully selected to bring about meaningful, measurable change. 

Whether you're addressing mental health, skin conditions, or chronic digestive imbalances, these formulas represent a new frontier in therapeutic intervention, where precision meets whole-body synergy. Because true transformation doesn't just feel better—it shows up in your biology.

Disclaimer: 

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.